Leuprolide Acetate should be stored in the original carton at room temperature below 77ºF until its ready to be used. Once opened Leuprolide Acetate should be refrigerated in the original carton. Do not freeze. Protect from light.
Leuprolide acetate is given via injections and inhibits the secretion of gonadotropins when given continuously and in therapeutic doses. This medication is used to achieve ovarian suppression. Once the ovaries are suppressed, your physician will prescribe an FSH in order to stimulate the ovaries to produce multiple follicles. Leuprolide acetate is used when going through ART.
Leuprolide injection comes as a long-acting suspension (Lupron) that is injected intramuscularly (into a muscle) by a doctor or nurse in a medical office or clinic and is usually given once a month (Lupron Depot, Lupron Depot-PED) or every 3, 4, or 6 months (Lupron Depot-3 month, Lupron Depot-PED-3 month, Lupron Depot-4 month, Lupron Depot-6 Month). Leuprolide injection also comes as a long-acting suspension (Eligard) that is injected subcutaneously (just under the skin) by a doctor or nurse in a medical office or clinic and is usually given every 1, 3, 4, or 6 months. Leuprolide injection also comes as a long-acting suspension (Fensolvi) that is injected subcutaneously (just under the skin) by a doctor or nurse in a medical office or clinic and is usually given every 6 months. Your doctor will tell you how long your treatment with leuprolide injection will last. When used in children with precocious puberty, leuprolide injection (Lupron Depot-PED, Lupron Depot-PED-3 month, Fensolvi) will likely be stopped by your child’s doctor before 11 years of age in girls and 12 years of age in boys.
If you receive leuprolide long-acting suspension (Eligard) as a subcutaneous injection, you may notice a small bump at the place where the injection was given when you first receive the medication. This bump should eventually go away.
Leuprolide may cause an increase in certain hormones in the first few weeks after injection. Your doctor will monitor you carefully for any new or worsening symptoms during this time.
There are three places that a subcutaneous injection may be given: the abdomen, the thigh, or the back of your arm as shown here
- Select your injection site (the abdomen is preferred)
- Cleanse the area with alcohol and let dry. Do not blow on it.
- Take a pinch of the fatty tissue you have cleansed. The injection is given here.
- Hold the syringe like a pencil or a dart approximately 1 inch away from the skin.
- Insert the needle quickly (not hard), with one fluid motion, into the skin.
- Let go of the pinch of skin. Depress the plunger and inject all of the medication. Pull the needle straight out.
- Apply pressure to the injection site with a sterile gauze pad.
- Never reuse needles or syringes.
- Dispose of the syringe in a biohazard container such as a Sharps container – or in a sealable, unbreakable plastic container such as a laundry detergent bottle.
Please be aware that some of these instructions may vary based on your particular situation or preference.